no nausea or vomiting with chemo

December 1, 2013 by  
Filed under Side Effects

This post send by kim

Please read more about fasting prior to chemotherapy drugs that usually make you sick with nausea and vomiting and are followed by other things such as mouth sores or mucousitis. This worked for my son who without fasting had Emend and steroids and zofran and ativan but still threw up 5-8/day before fasting. With fasting he threw up ZERO!

HERE IS ONE ARTICLE:
Fasting can protect cells from stress and damage, such as oxidation or radiation, and has been found to protect healthy cells from chemotherapy. But can the practice also help fight cancer?

There is now evidence to support this idea, from research on cancer models of yeast and tumor-ridden mice, published today (February 8) in Science Translational Medicine. Starved organisms survived longer when treated with chemotherapy than those on a normal diet, and healthy cells were less likely to sustain damage.

“This ability to think about adding fasting in combination with chemotherapy is obviously exciting, and it definitely adds something to the arsenal of what we can do,” said Trudy Oliver, who researches cancer resistance at the University of Utah but was not involved in the study.

Chemotherapy works by attacking rapidly dividing cells, a hallmark of cancer. Previous studies suggested that fasting before treatment could help protect healthy cells by slowing their growth even further. But one question loomed in researchers’ minds: “What happens to the cancer cells?” said study co-author Valter Longo, who studies the molecular mechanisms of aging at the University of Southern California. If fasting slowed down cancer cell growth enough to reduce the effectiveness of chemotherapy, “this would be a problem.”

Initial results in cancer-mimic yeast and cancerous mammalian cell lines provided Longo with evidence that starvation slows cancer growth and also enhances healthy cell survival when faced with chemotherapy. These results encouraged Longo to move into mouse models. “If it doesn’t change from yeast to mammalian cells, we figured that it is something so conserved and fundamental it’s going to apply to humans too,” he said.

Longo\’s team studied a variety of mouse models. Mice were injected with both human and mouse cancers, including breast cancer, melanoma, and the nervous system cancer neuroblastoma, among others. The researchers also tested several types of chemotherapy drugs. And each experimental combination was subjected to three treatments: just fasting, by being given only water for 48–60 hours prior to treatment, just chemotherapy, or fasting and chemo together.

Results varied by cancer type and treatment, but overall the combination of fasting and chemotherapy reduced cancer growth significantly, and starved mice survived far longer than their non-starved counterparts. For example, melanoma metastasis was found in 40 percent of mice given just chemotherapy, 20 percent under starving conditions alone, and 10 percent of mice that underwent chemotherapy and fasting.

“The surprising part was that, for several cancers including breast cancer, fasting cycles alone were as good as chemotherapy,” said Longo. “We expected some delay but not an equivalent effect.”

Gene expression assays and molecular analyses suggested that, in cancer cells but not healthy cells, fasting and chemo together induce a 20-fold increase in DNA damage, an increase in oxidative stress, and higher incidence of cleaved caspase 3, a protein that induces cell death.

Longo hypothesizes that, while normal cells are well-equipped to deal with starvation by slowing their metabolism to just essential activities, cancer cells “became better at growing and growing and worse at adapting to new conditions.” When cancerous cells are faced with a hostile environment, such as starvation, they become weak and shut down. “And, when they become weak, chemotherapy has an easier time,” he added. However, he emphasized, this is still a hypothesis.

While Oliver finds the results “provocative,” she would like to see the molecular mechanisms fleshed out more, especially because the pathway is so “counter-intuitive.”

“You might think it would work the other way: that chemo is not going to work as well anymore if you slow down cancer growth,” she said. Future studies should try to elucidate the mechanism and study the phenomenon in more in vivo cancer models to “show us the effect directly on proliferation as a result of that fasting,” she added.

There are already three clinical trials— one of which is at the University of Southern California—underway studying the combination of fasting and chemotherapy in human patients.

Longo suspects that the human equivalent of 48–60 hours of mouse fasting is about five days, based on glucose and growth factor concentrations. Five days is a long time, noted Oliver, and fasting “may be rough for cancer patients who are already going through a lot.” But uncovering the mechanism could lead to better solution, she added.

“It might be that people don’t need to starve to do the same thing, if they can take a new drug with chemotherapy that mimics starvation but is not as painful as starvation,” Oliver said. “That underscores the importance of finding the mechanism.”

C. Lee et al., \"Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy,\" Science Translational Medicine, doi:10.1126/scitranslmed.3003293, 2012

Needing advice or info. Plz help!!!

September 2, 2013 by  
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This post send by Savannah

Okay, so they switched my chemo to a regimen called folfox. Which is commonly used for colon cancer but in this case is being used for my liver cancer. Since I began this drug it has been soooo much worse than the other stuff I was on. I am having side effects which include the normal (fatigue, nausea, decreased appitite etc.) But now I also have new side effects which include painful tingling in my hands and feet when anything cold touches them, stinging in my throat when drinking anything cold, and more hair loss. These symptoms are normal for my chemo from what I am told. But my problem is that I am having certain side effects that my doctors are not able to explain. This includes increased urination sometimes and other times urinating without knowing it, extreme burning in my throat and chest whenever I eat anything (cold or hot) And sometimes when the burning occurs I feel as if I cant breath. Which is extremely terrifying. I would just like to know if anyone has had these symptoms on folfox or on any other chemo, and what I should do about it. Because my health is slowly getting worse when chemo is suppose to be curing my cancer. I know that chemo takes a huge toll on ur body but still… Also my doctors believe I may be contracting diabetes on this chemo, has this happened to anyone also? Any info or advice is greatly appreciated I am just starting to get scared and I am sorry to those of you who feel this is TMI but I just need to know if anyone else has experienced this. Thanks

PTSD

August 8, 2013 by  
Filed under Side Effects

This post send by Ivylin Cordova

Hi everyone my name is ivylin Cordova I\\\’m a cancer survivor and I have PTSD from it I was 13 when I had Rhabdomyosarcoma I was really scared when I found out I didn\\\’t know what to do I had really bad depression none of the people I went to middle school with know I had cancer only one knew my best friend I told her the day I found out she started to cry hard I cried hard to I couldn\\\’t breath for a moment I told her ill be ok ill be fine she said ok she asked me if anyone else knew I said only my family and you that\\\’s it and I was so angry,sad I didn\\\’t want to believe it had it a month after I turned 13 I wanted to cry I had it in my uterus I couldn\\\’t stop bleeding for 6 months I knew something was wrong so did my mom she told the doctors what was wrong with me they said it was regular teenage stuff I didn\\\’t believe it but I\\\’m 2 years cancer free I\\\’m 15 now I\\\’m great I have a beautiful girlfriend and I\\\’m proud to be bisexual ☺ CANCER SUCKS!!!!

Hair loss

June 16, 2013 by  
Filed under Side Effects

This post send by Rachael

In the span of about a month and a half I lost most of my hair. As I watched it fall out I put off shaving my head because I did not want to have no hair. Big mistake. If I could do it over again I would just shave it all off before the hair loss started. By the end I was starting to question my sanity as I cried myself to sleep every night, and cried every morning as I saw my pillow covered with hair. The bottom line? I can get used to having no hair but nothing could be more gross then rolling over and getting a mouth full of hair.

Help ppl think ima dude

I was diagnosed with AML back in december 11 2010. And i have lost all my hair(which is my pride) i was very strong bout it but now im startin to wear down because ppl are confusing me for a guy and im really upset bout it. my friends dont get it and idk what to do. someone please contact me. btw im 17

i have had a headache for the last two weeks if any one has any suggestions please let me no

First Round of Chemo tomorrow

I am no longer technically a teen… I just turned 20 in January.. but who’s counting really

I was diagnosed with a rare form of the Ewing’s Sarcoma family of tumors called PNET in February of this year.

I start my first round of an intense chemo cycle tomorrow.

Through out this whole thing I haven’t been scared of cancer, or death.. just the side effects and the things that I can’t predict.

I will loose my hair, probably blow up like a water balloon.. and apparently my nausea meds will make me super hungry so I could gain wait. I have never been one too worried about what people think of me and how I look. But now that my appearance is out of my control and I will have cancer patient written all over me.. I am so devastated.

How do you all handle the appearance changes?

xo K

hi my name is jeremiah i am starting a chat line for any one on here it will be a chat line number it is not only for people that went throo cancer but it is for adalts to email if interested in being apart @ jeremiahg20@gmail hope too here from you soon

hey

hey everyone. im new to this site. so i dont really know how it works. im 20 yrs old && i was diagnosed with a rare cervical cancer at 17 yrs old. i had to have a histerectomy && no longer have the abililty to bear children. i have had 3 re-occurences since then. im going through thte 3rd now. ive never been able to talk about how i feel with family or friends because they dont feel the same pain && hurt as i do. i was just wondering if there was anyone else on here who may have a cervical cancer or one similiar to mine. although being 20 yrs old im suppost to be strong && not worry but that really isnt true i just found out recently that im going to loose my hair && even though my wig is beautiful im still really upset about it. i know people have it much worse than me && i shouldnt be upset but ive never felt so alone && so unlike me in my whole life even when i had like 2 friends in school. i appreciate you reading what i have to say & & i really hope i can find someone or someones to talk to maybe my life wont feel so alone or worthless..thank you

cassi perrin

20 yrs old

War


Everything changes during a moment

Someone’s life begins while another ends

A smile turns into a frown

A room full of people turns into nothing

Everything you ever wanted to do,

Vanishes

Nothing else matters

Nothing else is important

You no longer belong to yourself

Everything you use to love,

no longer holds interest for you

Peace is no longer found in faces or places

War is lurking around th corner

The only thing that matters

The only thing that is important

Surviving.

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