no nausea or vomiting with chemo

December 1, 2013 by  
Filed under Side Effects

This post send by kim

Please read more about fasting prior to chemotherapy drugs that usually make you sick with nausea and vomiting and are followed by other things such as mouth sores or mucousitis. This worked for my son who without fasting had Emend and steroids and zofran and ativan but still threw up 5-8/day before fasting. With fasting he threw up ZERO!

Fasting can protect cells from stress and damage, such as oxidation or radiation, and has been found to protect healthy cells from chemotherapy. But can the practice also help fight cancer?

There is now evidence to support this idea, from research on cancer models of yeast and tumor-ridden mice, published today (February 8) in Science Translational Medicine. Starved organisms survived longer when treated with chemotherapy than those on a normal diet, and healthy cells were less likely to sustain damage.

“This ability to think about adding fasting in combination with chemotherapy is obviously exciting, and it definitely adds something to the arsenal of what we can do,” said Trudy Oliver, who researches cancer resistance at the University of Utah but was not involved in the study.

Chemotherapy works by attacking rapidly dividing cells, a hallmark of cancer. Previous studies suggested that fasting before treatment could help protect healthy cells by slowing their growth even further. But one question loomed in researchers’ minds: “What happens to the cancer cells?” said study co-author Valter Longo, who studies the molecular mechanisms of aging at the University of Southern California. If fasting slowed down cancer cell growth enough to reduce the effectiveness of chemotherapy, “this would be a problem.”

Initial results in cancer-mimic yeast and cancerous mammalian cell lines provided Longo with evidence that starvation slows cancer growth and also enhances healthy cell survival when faced with chemotherapy. These results encouraged Longo to move into mouse models. “If it doesn’t change from yeast to mammalian cells, we figured that it is something so conserved and fundamental it’s going to apply to humans too,” he said.

Longo\’s team studied a variety of mouse models. Mice were injected with both human and mouse cancers, including breast cancer, melanoma, and the nervous system cancer neuroblastoma, among others. The researchers also tested several types of chemotherapy drugs. And each experimental combination was subjected to three treatments: just fasting, by being given only water for 48–60 hours prior to treatment, just chemotherapy, or fasting and chemo together.

Results varied by cancer type and treatment, but overall the combination of fasting and chemotherapy reduced cancer growth significantly, and starved mice survived far longer than their non-starved counterparts. For example, melanoma metastasis was found in 40 percent of mice given just chemotherapy, 20 percent under starving conditions alone, and 10 percent of mice that underwent chemotherapy and fasting.

“The surprising part was that, for several cancers including breast cancer, fasting cycles alone were as good as chemotherapy,” said Longo. “We expected some delay but not an equivalent effect.”

Gene expression assays and molecular analyses suggested that, in cancer cells but not healthy cells, fasting and chemo together induce a 20-fold increase in DNA damage, an increase in oxidative stress, and higher incidence of cleaved caspase 3, a protein that induces cell death.

Longo hypothesizes that, while normal cells are well-equipped to deal with starvation by slowing their metabolism to just essential activities, cancer cells “became better at growing and growing and worse at adapting to new conditions.” When cancerous cells are faced with a hostile environment, such as starvation, they become weak and shut down. “And, when they become weak, chemotherapy has an easier time,” he added. However, he emphasized, this is still a hypothesis.

While Oliver finds the results “provocative,” she would like to see the molecular mechanisms fleshed out more, especially because the pathway is so “counter-intuitive.”

“You might think it would work the other way: that chemo is not going to work as well anymore if you slow down cancer growth,” she said. Future studies should try to elucidate the mechanism and study the phenomenon in more in vivo cancer models to “show us the effect directly on proliferation as a result of that fasting,” she added.

There are already three clinical trials— one of which is at the University of Southern California—underway studying the combination of fasting and chemotherapy in human patients.

Longo suspects that the human equivalent of 48–60 hours of mouse fasting is about five days, based on glucose and growth factor concentrations. Five days is a long time, noted Oliver, and fasting “may be rough for cancer patients who are already going through a lot.” But uncovering the mechanism could lead to better solution, she added.

“It might be that people don’t need to starve to do the same thing, if they can take a new drug with chemotherapy that mimics starvation but is not as painful as starvation,” Oliver said. “That underscores the importance of finding the mechanism.”

C. Lee et al., \"Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy,\" Science Translational Medicine, doi:10.1126/scitranslmed.3003293, 2012

Germ cell, my story so far.

May 21, 2011 by  
Filed under Community

Hi, my name’s Ellie and I’m 19 years old. I was in the middle of my first year at university and was having water infections and unexplained fatigue, days where I literally stopped being able to do anything from exhaustion. After about 3 times of being precribed antibiotics for the infections, I decided to push for more explanation to why I was getting ill all the time. A GP found a lump in my abdomen and suspected it to be a dermoid cyst, but on the 23/03/11 an MRI revealed that I had a 14x11x10cm germ cell tumour on my left ovary. A CT scan and biopsy showed that I also had a smaller tumour on my right ovary (approx 4cm) and that the cancer had spread to my lymph nodes. Germ cell is a rare cancer affecting mostly younger women, only 1% of ovarian cancers are the same as mine.
I suspended my studies (hope to start my first year of uni again next year) and moved out of student halls where I had lived whilst at uni, to come and live at home with my parents while I undergo chemotherapy. I’m 2 courses into a projected 4 x BEP 5 day regieme. It’s definitely tough, I’m getting all the usual side effects including tinnitus, nausea, aches in my lymph nodes, neuropathy in my legs, hairloss, mouth ulcers and “chemo-brain”. I’m also experiencing the menopause complete with hot flushes because my ovaries have been “put to sleep” with the hope that I will recover fertility after treatment. There haven’t been any serious hiccups in the treatment so far. There’s currently a little concern about my lung function and possible damage by bleomycin (I got a cough 3 weeks ago and it still hasn’t shifted), and I had a low white count on a check up in my first round so I had a 5 day course of blood boosters, which gave me quite a lot of pain in my legs and lower back. In the second round when I was in hospital recieving chemo, they spotted I get a very low heart rate at night (about 40bpm) and this is also being checked out.
Even though this whole experience has completely upturned my life I remain positive. One thing I did before I went for my first round of chemo is raise some money for Cancer Research UK and awareness for germ cell and ovarian cancers by cutting my hair into a mohawk! I came to this website to try and meet other people in my situation and have people to talk to who can really relate to all this. I’m always up for a chat!

I also have a personal/cancer journey blog at :)

July 9, 2010 by  
Filed under Side Effects

I was diagnosed with ALL on September 29,2009.  Since then, I’ve finished my freshmen year of high school at home and finished 3 phases of chemotherapy treatment.  Now I’m in maitenance and it’s supposed to be the easiest phase, but its been pretty difficult so far.  Instead of spending 4th of July in Disneyworld like I was supposed to, I was stuck in the hospital with a fever and super low blood counts.  I’ve been off most of my chemo for about a month now because I had a rash, but my blood counts are still taking forever to improve.  It’s really frustrating because it’s preventing me from going on my vacations and going out with my friends.  It’s hard to explain this to any of my friends because they don’t truely understand.  They just keep telling me to stay strong, but in order to stay strong you had to be strong in the first place and I don’t feel very strong.  To top it all off, all of the changes that my body has been going through has made me extremely self conscious.  I didn’t lose all of my hair, but it is significantly thinner, I’ve gained about 15-20 pounds, and I have tons of stretchmarks, oh yeah and my face has become the roundest thing I’ve ever seen.  I handled everything really well for the past 10 months, but now I’m really starting to lose it. Thanks for letting me vent.

Chemo, love hate relationship.

June 14, 2010 by  
Filed under Coping with Cancer, Side Effects

I hate chemo. I hate it so much, the nausea, the jelly knees, the fatigue, the vomitting, the hair in the bottom of the shower and all over my pillow and in my hands. There are so many terrible side effects, the cure can be worse than the disease.

However, its the cure, and it will make me better. Its the only thing that will get rid of the cancer, and its helping me.

Its very weird to hate the thing saving your life this much.

So…sick… I hate chemo treatments.

My name is Caleb. I’m 17, and I have Leukemia. I was diagnosed almost a month ago now, and I’m starting my Chemotherapy. Yesterday afternoon, I started my second round.

Thank God the first round was easy on me. This second round is really kicking my butt.

I didn’t feel really well yesterday morning, anyways. And I had the option of either having the treatment this morning, or yesterday afternoon at 4, and I opted for yesterday afternoon, because I had a track meet this morning.

I got there around 4:00, and they hooked me up. I sat in the seat, and waited for it to finish dripping.

Halfway through, I got a HUGE headache. I mean, this was the worst pain I’ve ever had in my head. It felt like someone was hitting me in the head with a hammer.

I finished and went home about 2 hours later, after talking to some really close friends in the treatment place.

I got home, and went to lie down and watch a movie. My head was still pounding.

This morning, I woke up, and automatically felt sick. I stood up, and I was extremely dizzy. I spent the better part of the morning in and out of the restroom, and sleeping on the bathroom floor. I hate that.

I was usually pretty healthy. I never got sick before all of this happened, and I’m not used to it. I don’t like it.

After my numerous restroom trips, I finally worked up enough strength to make it down stairs to say good morning to my amazing mother, and I sat down at the kitchen table, and laid my head down. My mom felt my forehead, and took my temp and all that. Granted- she’s not used to this quite yet, either. She’s used to healthy kids, I mean, none of my 5 brothers have ever had anything that compares to this, and neither has my sister. Quite frankly, neither have I. She’s not very fond of us being sick at all, I mean, the flu season is a terrible time for her! I was running a fever of like… 102, I think. And my head was still killing me.

She sent me to lie on the living room couch, and when I laid down, I turned on Fired Up!, and soon fell asleep.

I woke up about an hour later, and I felt a HUGE surge of nausea, and I leapt for the restroom.

See, now, this is where my story gets pretty pitiful. I hate being sick. SO much. I absolutely despise it. But I’m smart enough to expect it with Chemo.

So, I spent a lot of my afternoon throwing up, and falling asleep, and throwing up, and falling asleep again, and on and on.

Needless to say, I didn’t have a very good day.

I hate Chemo treatments.

Who’s with me?

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